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Important Safety Information

Tobramycin is a prescription medication used to treat infections in adult patients.

Prior to starting treatment, talk to your doctor about your medical history — especially if you are allergic to any medication or antibiotic. Also, mention all medications you’re currently taking, regardless of whether they’re prescription, over-the-counter, vitamins, or herbal supplements. This is recommended to prevent a harmful interaction from mixing drugs — as Tobramycin has serious interactions with at least 25 medications, and mild to moderate interactions with more than 130 medications.

Tell your doctor if you’re pregnant or are planning on becoming pregnant so that you can discuss the risks and benefits of taking the medication. Tobramycin may also be passed to your baby through breast milk, therefore, talk with your doctor about feeding alternatives if you’re currently breastfeeding.

What is the most important information I should know about Tobramycin?

There is a heightened risk of kidney damage in patients with a history of kidney disease, as well as in patients with a normal kidney function who are treated at higher doses and/or for longer periods of time than what’s medically necessary. Babies and infants should be closely monitored and the medication should be used with caution to prevent the medication from affecting their kidneys.

Avoid taking diuretics while undergoing treatment with Tobramycin, as doing so could increase the risk of temporary or permanent hearing loss. In addition, Tobramycin may cause neuromuscular blockage and/or respiratory paralysis — particularly if administered soon after taking muscle relaxants or undergoing anesthesia.

Side Effects of Tobramycin

As with any prescription medication, Tobramycin carries the risk of side effects. The most common ones include:

  • Vertigo
  • Drowsiness
  • Headaches
  • Nausea
  • Vomiting
  • Joint pain
  • Weakness
  • Shaking
  • Hearing loss
  • Tearing
  • Itching, stinging, or burning of the eyes
  • Eye swelling
  • Inflammation of the cornea
  • Blurred vision
  • Kidney damage
  • Low blood pressure

Seek medical care if you experience any side effects — especially if they don’t seem to go away. Pay attention to signs of an allergic reaction, such as breathing difficulties, chest tightness, skin rash, fever, and/or swelling of the face, throat, lips, and/or tongue.

Tell your doctor if you experience any negative side effects. You are also encouraged to report such side effects to the Food and Drug Administration (FDA) by visiting, or by calling 1-800-FDA-1088.


Tobramycin is used to treat infections. Dosages may have to be modified in elderly patients to reduce the risk of nephrotoxicity and ototoxicity. Dose reductions are also required for patients with diminished renal function.

Please refer to the full prescribing information.