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Important Safety Information

Promethazine is a group of prescription medications used to affect the chemicals in the brain. It also works by blocking histamine — making it an ideal treatment to treat allergic reactions. It also helps alleviate symptoms related to motion sickness, nausea, vomiting, and post-operative pain.

Promethazine may cause extreme drowsiness. Therefore, when planning your treatment, make sure to have someone who’ll be able to drive you home from each session. Also, avoid consuming alcohol when undergoing treatment with Promethazine, as mixing both substances could make the drowsiness even more severe and last longer.

Promethazine could interact with other medications. Tell your doctor of all drugs you’re currently taking — regardless of whether they’re prescription, over-the-counter, herbal supplements, or vitamins. It could have an especially adverse effect on you if mixed with antidepressants or medications to treat anxiety, allergies, pain, nausea, sleeping difficulties, seizures, gastrointestinal issues, and Parkinson’s disease.

Promethazine may harm an unborn child, and it can pass into breast milk and cause side effects in your baby. Therefore, talk with your doctors about your options if you’re pregnant or breastfeeding. The medication could also reduce mental alertness in senior patients.

What is the most important information I should know about Promethazine?

Promethazine may cause breathing problems in young children. Do not use the medication to treat infants two years of age or younger, as this could result in a slower breathing rate and even death. In addition, children who are currently being treated with other medications should not be treated with Promethazine.

Tell your doctor about your medical history — especially if you suffer from glaucoma, gastrointestinal problems, an enlarged prostate, bladder issues, heart, liver, or bone marrow disease, sleep apnea, seizures, or chronic obstructive pulmonary disease (COPD), as Promethazine may worsen symptoms associated with these conditions.

Side Effects of Promethazine

As with any prescription medication, Promethazine carries the risk of side effects. The most common ones include:

  • Dry mouth
  • Stuffy nose
  • Extreme drowsiness
  • Excitability
  • Nervousness
  • Unusual body movements
  • Allergic reactions
  • Changes in blood pressure
  • Reduced white blood cell production

In rare cases, you may experience more serious side effects. Seek emergency medical care immediately if you experience any of the following symptoms:

  • Fever
  • Breathing difficulties
  • Dizziness
  • Lightheadedness
  • Confusion
  • Hallucinations
  • Eye or lid twitching
  • Uncontrollable muscle contractions
  • Involuntarily sticking out your tongue
  • Chest pain
  • Palpitations
  • Bruising
  • Abnormal bleeding
  • Blood in your urine
  • Black tarry stools
  • Clay-colored stools
  • Hives
  • Swelling on your face, hands, and/or feet
  • Increased sweating
  • Yellow skin
  • Fainting
  • Seizures

Tell your doctor if you experience any negative side effects. You are also encouraged to report such side effects to the Food and Drug Administration (FDA) by visiting, or by calling 1-800-FDA-1088.


Promethazine is used to treat motion sickness, nausea, vomiting, allergic reactions, and post-operative pain in some pediatric and adult patients. The dosage will vary depending on the person’s age, medical history, the condition being treated, and the severity of the condition.

Please refer to the full prescribing information.