Rocephin (Ceftriaxone)
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Important Safety Information

Rocephin (ceftriaxone) is a cephalosporin antibiotic infusion used to treat bacterial infections such as:

To maintain the effectiveness of ceftriaxone and other antibacterial treatments and to reduce the likelihood of the development of drug-resistant bacteria, ceftriaxone infusions should only be administered for infections that are proven or strongly suspected to be caused by susceptible bacteria.

What is the most important information I should know about ceftriaxone?

Talk to your healthcare provider before receiving ceftriaxone infusion, especially if you have:

  • Liver, kidney, or gallbladder disease
  • Diabetes
  • An allergy to penicillin
  • Colitis or other digestive conditions
  • Any condition requiring a blood thinner
  • Poor nutrition

You should not receive Rocephin infusions if you have ever had an allergic reaction to any cephalosporin antibiotics, including ceftriaxone.

If you are currently taking any other prescription or over-the-counter medications, talk to your doctor before receiving ceftriaxone, as it may interact with other drugs.

Dosage Information

Ceftriaxone infusions for adults usually consist of a daily dose of 1 to 2 grams, depending on the particular infection and its severity. The duration of the therapy generally lasts from 4 to 14 days. In some cases, longer treatment may be necessary.

For children, the recommended daily dosage ranges from 50-100 mg/kg administered once daily, depending on the treatment type. The typical duration for pediatric treatment with ceftriaxone is 7 to 14 days.

Side Effects of Ceftriaxone

Though not exhaustive, some of the common side effects of ceftriaxone include:

  • Nausea, vomiting, and loss of appetite
  • Headache and dizziness
  • Sweating
  • Upset stomach
  • Vaginal itching
  • Vaginal yeast infection
  • Anemia
  • Changes in taste
  • Flushing
  • Pain or swelling in your tongue
  • Reactions at the injection site, such as swelling, redness, and soreness
  • Diarrhea

If you experience any severe reactions to ceftriaxone, such as an allergic reaction, severe skin reaction, or seizure, contact your doctor or seek emergency medical help.

In rare cases, patients may experience more serious side effects. Seek emergency medical care immediately if you notice any of the following symptoms:

  • Signs of anaphylaxis — such as breathing difficulties, wheezing, dizziness, skin reactions, nausea, vomiting, diarrhea, and/or faining
  • Yellowing of the skin or whites of the eyes
  • Blood in your urine
  • Palpitations
  • Seizures

To report side effects of ceftriaxone, contact the Food and Drug Administration (FDA) by visiting, or by calling 1-800-FDA-1088.


Rocephin (ceftriaxone) is indicated for the treatment of bacterial infections of the lower respiratory tract, skin and skin structure, bone and joint, UTIs, septicemia, intra-abdominal infections, meningitis, and uncomplicated surgical prophylaxis.

Please refer to the full prescribing information.