Reclast (Zoledronic Acid)
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What is Reclast?

Reclast (zoledronic acid) is an infusion medication used to treat Osteoporosis.

Important Safety Information

Reclast may interact with other medications. Tell your doctor about all drugs you’re currently taking — whether they’re prescription, over-the-counter, vitamins, or herbal supplements. It may especially cause harm to your kidneys if mixed with diuretics, antibiotics, nonsteroidal anti-inflammatory drugs, antiviral medications, drugs to treat bowel disorders, cancer medications, and drugs to prevent organ transplant rejection.

Reclast can potentially harm a fetus, but it is unknown whether the medication can be passed on to your baby via breast milk. Therefore, talk with your doctor about possible options if you are pregnant or breastfeeding, or are planning on breastfeeding.

What is the most important information I should know about Reclast?

Patients who are experiencing low calcium levels must treat such condition before starting treatment with Reclast, as the medication may worsen the condition. In addition, such patients may need to supplement with calcium and vitamin D. It may also be necessary to conduct bone density tests throughout treatment.

Reclast Dosage Information

A single dose of Reclast is a 5mg/100mL solution of Zoledronic acid, which is administered intravenously via infusion. IV infusions of Reclast take 30 minutes to complete. For treatment of osteoporosis, patients receive one 5mg dose per year. For all treatments, supplementation with calcium and Vitamin D is generally prescribed. Consult your doctor or infusion provider for more information about Reclast dosing.

Reclast and Kidneys

Reclast may be harmful to your kidneys — especially if you have experienced certain medical ailments in the past. Discuss your medical history with your doctor, particularly if you have a history of any of the following conditions:

  • Kidney disease
  • Dark-colored urine
  • Dry skin
  • Infections
  • Inability to drink enough fluids
  • Dehydration
  • Excessive or decreased sweating

Does Reclast cause hair loss?

Like other bisphosphonate medications, Reclast has been linked to hair loss and/or thinning of hair in some patients. Researchers have not been able to explain fully why this occurs, though some have suggested it has to do with how the drug interacts with cholesterol levels in the hair. It is possible that there is no direct link between bisphosphonates and hair loss, but since some patients have reported hair loss in association with taking Reclast, you should be aware of the possibility and consult your doctor if you have concerns about this or any other possible side effects.

Reclast Side Effects

As with any prescription medication, Reclast carries the risk of side effects. The most common side effects of Reclast include:

  • Tiredness
  • Headaches
  • Dizziness
  • Coughing
  • Nausea
  • Diarrhea
  • Constipation
  • Joint pain
  • Muscle pain
  • Hair loss
  • Sleeping difficulties
  • Loss of appetite
  • Stomach pain
  • Heartburn
  • Redness or itching at the site of injection
  • Swelling, redness, irritation, or itching/burning of the vagina
  • Flu-like symptoms

Patients who experience flu-like symptoms typically feel them after the first treatment — and they generally see an improvement within 48 hours. Less common side effects include heartburn, stomach ulcers, and swallowing difficulties. Alcohol will worsen symptoms of side effects.

In rare cases, Reclast may cause more serious side effects. Seek emergency medical care immediately if you experience any of the following symptoms:

  • Breathing difficulties
  • Chest tightness
  • Confusion
  • Numbness or tingling around the mouth
  • Easy bruising
  • Weakness
  • Severe pain
  • Pale skin
  • Unusual pain in the groin area
  • Little to no urination
  • Extreme fatigue
  • Signs of infection — such as fever, chills, hives, or swelling
  • Loosening of the teeth
  • Painful or swollen gums
  • Osteonecrosis of the jaw

Osteonecrosis of the jaw is more likely to occur in patients who undergo dental surgery while treating with Reclast. It can also occur if you’re undergoing chemotherapy, radiation treatments, or have a blood disorder.

Tell your doctor if you experience any negative side effects. You are also encouraged to report such side effects to the Food and Drug Administration (FDA) by visiting, or by calling 1-800-FDA-1088.


Reclast is used to treat Paget’s disease, multiple myeloma, any type of cancer that spreads to the bone, osteoporosis, and high blood levels of calcium caused by cancer. The dosage will vary depending on the condition being treated.

Please refer to the full prescribing information.