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What is Reclast?

Reclast (zoledronic acid or zoledronate) is an intravenous antibiotic that slows down bone loss — making it ideal to treat Paget’s disease of the bone, osteoporosis caused by menopause, gonadal failure, or steroid use. It is administered on patients who are at high risk of bone fractures.

What are the most important things I should know about Reclast?

Women who are pregnant should not take Reclast, as it may harm the unborn baby. In addition, avoid getting pregnant if you’re currently taking Reclast to treat any medical condition. If you’re thinking of starting a family, talk to your doctor about its viability.

Reclast may also cause serious kidney problems — especially if you already have kidney disease, are taking diuretics, or are often dehydrated.

Your doctor may also recommend that you undergo a dental exam for preventive oral health care prior to starting treatment — especially if you are undergoing chemotherapy or using steroids.

Drink at least two glasses of water within a few hours prior to your IV treatment to avoid becoming dehydrated. You may also have to take calcium supplements and follow a specific diet, per your doctor’s instructions.

Avoid smoking, as doing so reduces your bone density, increasing the likelihood of fractures.

Tell your doctor if you have a history of any of the following conditions:

  • Kidney disease
  • Hypocalcemia
  • Thyroid surgery
  • Parathyroid surgery
  • Surgery to remove a portion of your intestines
  • Asthma caused by taking aspirin
  • Malabsorption of nutrients
  • Dental problems

What are the common side effects of Reclast?

Call your doctor immediately if you experience any of the following side effects:

  • Muscle spasms
  • Numbness
  • Tingling
  • Hip pain
  • Joint pain
  • Jaw pain, swelling, or numbness — especially if you have cancer
  • Loose teeth
  • Gum infection
  • Breathing difficulties

Additional side effects may include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Fever
  • Flu symptoms
  • Red or puffy eyes
  • Headaches
  • Fatigue

These are not all of the possible side effects of Reclast. Talk to your doctor about any side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.