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What is OCTAGAM®?

OCTAGAM® is a prescription infusion medication used to treat adult patients with chronic immune thrombocytopenic purpura (cITP) to raise platelet counts and control bleeding. It is contraindicated in patients with a history of severe systemic hypersensitivity reactions, to human immunoglobulin, and IgA-deficient patients with antibodies against IgA.

Important Safety Information

Although OCTAGAM® is efficient in treating cITP, it can also increase the risk of thrombosis, especially in patients of advanced age. Those with a history of venous or arterial thrombosis, prolonged immobilization due to bed rest, and patients with indwelling central vascular catheters, hyperviscosity, and cardiovascular disease are also at a higher risk.

OCTAGAM® may also increase the risk of renal dysfunction, acute renal failure, and osmotic nephrosis. It can also increase the chance of death in patients with pre-existing renal insufficiency, diabetes mellitus, sepsis, paraproteinemia, those receiving nephrotoxic medications, and individuals who are over 65 years of age.

Talk to your doctor about your medical history to determine whether OCTAGAM® is a good form of treatment for you — at the minimum required dose and infusion rate — or whether you should bypass it altogether. If your medical provider determines you can go ahead with treatment, you will be monitored throughout the infusion for signs of thrombosis. Staying hydrated will be crucial to protect your health.

OCTAGAM® may interact with other medications. Tell your doctor about all drugs you’re currently taking — whether they’re prescription, over-the-counter, vitamins, or herbal supplements.

What is the most important information I should know about OCTAGAM®?

OCTAGAM® contains maltose — a component that is derived from corn. Therefore, it may cause hypersensitivity in patients with corn allergies. The medication is also made from human plasma. Therefore, although small, there’s always a risk of containing infectious agents, such as viruses.

Patients who are at higher risk of renal failure should monitor their renal function and urine output. Patients who receive high doses or rapid infusion treatment are at higher risk of developing aseptic meningitis.

OCTAGAM® may cause false elevated blood glucose readings while undergoing infusion therapy. Patients undergoing treatment may develop hemolysis, due to enhanced red blood cell sequestration.

OCTAGAM® Side Effects

As with any prescription medication, OCTAGAM® carries the risk of side effects. The most common side effects include:

  • Headache
  • Fever
  • Increased heart rate

Seek medical care immediately if you experience symptoms of an allergic reaction. This includes itching, breathing difficulties, skin rash, and/or swollen mouth, lips, and face.

Tell your doctor if you experience any negative side effects. You are also encouraged to report such side effects to the Food and Drug Administration (FDA) by visiting www.fda.gov/medwatch, or by calling 1-800-FDA-1088.


OCTAGAM® is a prescription infusion medication used to treat adult patients with chronic immune thrombocytopenic purpura (cITP). The recommended dosage may vary depending on the patient’s age and medical history.

Please refer to the full prescribing information.