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Important Safety Information

Methylprednisolone is a corticosteroid. As such, it reduces and prevents inflammation. Therefore, it is an ideal form of treatment for patients with medical conditions that result in inflammation — including endocrine disorders, serious allergic reactions, arthritis, psoriasis, lupus, and ulcerative colitis, among others.

Methylprednisolone could make a patient experience withdrawal symptoms if treatment is stopped suddenly. Prior to commencing treatment, talk to your doctor about the best dosage and tapering plans for you to avoid such symptoms.

Methylprednisolone may also increase blood glucose levels. Therefore, tell your doctor if you have diabetes, as it may be necessary to modify the dosage of your diabetes medications.

What is the most important information I should know about Methylprednisolone?

There are a lot of medications that don’t interact well with corticosteroids. Tell your doctor about all drugs you’re taking, regardless of whether they’re prescription, over-the-counter, herbal supplements, or vitamins. In addition, you should avoid live vaccines while undergoing treatment with methylprednisolone.

Methylprednisolone may also affect the results of certain medical tests. Therefore, tell all medical providers who are treating you that you’re undergoing treatment with this medication.

Corticosteroids may also weaken your immune system — leaving you susceptible to infections. Talk to your doctor about your entire medical history, especially about recent illnesses and infections, especially if you’ve experienced any of the following conditions:

In addition, avoid being in close contact with individuals who have recently been sick or have had infections. This is a preventive measure to avoid contagion, since methylprednisolone can weaken your immune system.

Side Effects of Methylprednisolone

As with any prescription medication, Methylprednisolone carries the risk of side effects. The most common ones include:

  • Dizziness
  • Headaches
  • Mild muscle pain
  • Mild weakness
  • Bloating
  • Fluid retention in your hands and/or ankles
  • Changes in menstruation
  • Acne
  • Increased hair growth
  • Insomnia
  • Restlessness
  • Irritation of the stomach

In rare cases, patients who are treated with methylprednisolone may experience more serious side effects. Seek emergency medical care immediately if you experience any of the following symptoms:

  • Shortness of breath
  • Irregular heartbeats
  • Coughing up blood
  • Rapid weight gain
  • Blurred vision or tunnel vision
  • Seeing halos around light
  • Eye pain
  • Bruising
  • Thinning skin
  • Blood in your stools
  • Leg cramps
  • Pain in your back and/or limbs
  • Changes in personality
  • Severe depression
  • Numbness or tingling
  • Constipation
  • Fluttering in your chest
  • Increased thirst
  • Increased urination

Tell your doctor if you experience any negative side effects. You are also encouraged to report such side effects to the Food and Drug Administration (FDA) by visiting, or by calling 1-800-FDA-1088.


Methylprednisolone is used to treat medical conditions that cause inflammation, such as arthritis, endocrine disorders, autoimmune disorders, and serious allergic reactions. Dosages may vary from person-to-person, so you should talk to your doctor about what is appropriate.

Please refer to the full prescribing information.