Cytoxan (Cyclophosphamide)
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Important Safety Information

Cytoxan (cyclophosphamide) is a prescription infusion medication used to treat certain types of cancer and other non-cancer diagnoses. At Infusion Associates, Cytoxan is used for the treatment of non-cancer diagnoses.

Treatment with Cytoxan may result in hemorrhagic cystitis and/or heart damage or failure. If you have a history of cystitis, your doctor should conduct regular urine tests to monitor red cell count. Talk with your doctor in detail about your medical history to conduct a risk/benefit assessment. Also mention all medications you’re currently taking — whether they’re prescription, over-the-counter, vitamins, or herbal supplements.

Cytoxan will suppress your immune system — leaving you prone to infections. Severe allergic reactions have also been reported in some patients. Tell your doctor immediately if you experience hives, skin rash, chest tightness, breathing difficulties, fast heartbeat, and/or a swollen face, lips, or tongue.

What is the most important information I should know about Cytoxan?

Cyclophosphamide may cause fetal harm and birth abnormalities. There have also been normal births reported in women who have been treated with the medication. The medication can also be passed to your baby through breast milk, which could cause serious adverse reactions to your child. Talk with your doctor if you’re pregnant, are planning on becoming pregnant, or are breastfeeding to discuss your options.

Cytoxan could also cause infertility in both sexes. The risk depends on the dosage and duration of treatment. In some patients, the infertility is irreversible. The medication can also cause amenorrhea. However, menstruation is generally resumed within a few months after finishing treatment. While sexual libido is unaffected, men may develop a low sperm count. Cytoxan may also interfere with wound healing.

Side Effects of Cytoxan

As with any prescription medication, Cytoxan carries the risk of side effects. The most commonly reported ones include:

  • Loss of appetite
  • Upset stomach
  • Nausea
  • Vomiting
  • Diarrhea
  • Darkening of skin color
  • Wounds that won’t heal
  • Missed menstrual periods
  • Hair loss

More serious side effects have been reported in some individuals. Tell your doctor immediately if you experience any of the following:

  • Mouth sores
  • Extreme fatigue
  • Easy bruising or bleeding
  • Weakness
  • Joint pain
  • Burning sensation when urinating
  • Blood in urine
  • Blood in diarrhea
  • An unusual decrease in the amount of urine
  • Jaundice (yellowing of the skin)
  • Pneumonitis (inflammation of the lungs)
  • A fever of 100.4 F (38 C) or higher

In rare cases, patients may develop second malignancies. These cancerous growths could occur several years after treatment has been discontinued. Patients with a history of hemorrhagic cystitis have reported malignancies on their bladder.

Tell your doctor if you experience any negative side effects. You are also encouraged to report such side effects to the Food and Drug Administration (FDA) by visiting, or by calling 1-800-FDA-1088.


The dosage will vary from person-to-person. It commonly depends on the patient’s height, weight, type of cancer, and medical history.

Please refer to the full prescribing information.